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Yuan Yuan M.D., Ph.D.
Research performed at: City of Hope Comprehensive Cancer Center
Specialty/Research Area: Breast Cancer
Award Year: 2015, 2014

Career Summary: Dr. Yuan is an Assistant Professor in the Department of Medical Oncology and Molecular Therapeutics at City of Hope (Duarte, CA). Her primary research focus is discovery of novel therapeutics in overcoming therapy resistance including endocrine therapy resistance and chemotherapy resistance in breast cancer. In addition, she is interested in performing correlative, translational studies in order to identify clinically relevant biomarkers for breast cancer early detection, prognosis and prediction of treatment response. Dr. Yuan received her bachelor of medicine degree from Xuzhou Medical College in Xuzhou, China (1994), and an M.S. in oncology from Peking Union Medical College in Beijing, China (1997).  She went on to complete a Ph.D. in biochemistry and molecular biology from the University of California, Riverside (2002). She then completed a research fellowship at the Scripps Research Institute in La Jolla, CA (2003), followed by an internship and residency in internal medicine at the New York Downtown Hospital in New York, NY(2006).  She furthered her training with a hematology and oncology fellowship at the New York University Medical Center (2009).

In addition to her STOP CANCER Award, she is also the principal investigator on a Susan G. Komen grant to ascertain impediments to clinical trials enrollment for underrepresented minority female breast cancer patients (2010-2012).

Year STOP CANCER Award was received:  2015 Margie & Robert E. Petersen Foundation RCDA, 2014 Marni Levine Memorial Seed Grant

Description of research performed: Breast cancer cells were found to be auxotrophic for arginine, which provides the rationale for arginine deprivation as a treatment strategy. In the current research project, an arginine depleting enzyme will be studied extensively utilizing breast cancer cell lines.

Results of research: The preclinical results generated from this research projects will be utilized for design of phase I clinical trials which will directly benefit breast cancer patients in need.



STOP CANCER is committed to funding the most promising and innovative scientists in their early research of all forms of cancer prevention, treatment, cures and subsequent clinical applications. STOP CANCER works primarily with local National Cancer Institute-designated Comprehensive Cancer Centers and other qualified institutions in the United States to carry out its mission.

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