Career Summary: Dr. Andrew Goldstein is an Assistant Professor in the Departments of Molecular, Cell & Developmental Biology and Urology at the David Geffen School of Medicine at UCLA where his laboratory studies the cellular and molecular basis of prostate cancer. Dr. Goldstein was raised outside of Boston in Milton, MA. He studied Biochemistry and Molecular Biology and was a two-time NCAA Division 1 All-American lacrosse player at Dartmouth College. After working as a research technician at the Dana Farber Cancer Institute and a brief career playing for the Long Island Lizards of Major League Lacrosse, he moved to UCLA to pursue a Ph.D. in Molecular Biology. He began working in the area of prostate cancer in the laboratory of Dr. Owen Witte where he identified the first cell of origin for human prostate cancer and published this work as a first author in Science magazine. He went on to become the Inaugural Fellow of the Broad stem cell Research Center at UCLA, starting his own laboratory and receiving both a Young Investigator Award from the Prostate Cancer Foundation and an Idea Development Award from the Department of Defense Prostate Cancer Research Program. Since joining the faculty, Dr. Goldstein has received funding from the Margaret E. Early Medical Research Trust to pursue mechanisms of prostate cancer initiation and progression.
Year STOP CANCER Award was received: 2017 STOP CANCER Research Career Development Award
Description of research performed: Dr. Goldstein’s research is focused on the intersection between cancer biology, stem cell biology and metabolism with the goal of identifying cellular and molecular mechanisms promoting prostate cancer initiation, progression and treatment-resistance. He has described the identification of several stem and progenitor cell-types from the mouse and human prostate and has used this approach to discover candidate therapeutic targets in prostate cancer including Trop2. His recent work has addressed the effects of inflammation on progenitor cells that can initiate cancer.
Dr. Andrew Goldstein of UCLA uses walnuts to explain his latest research about chronic inflammation and it’s link to increased risk for prostate cancer.